Multiple genetic mutations associated with polymyxin resistance in Acinetobacter baumannii

Tze Peng Lim, Rick Twee Hee Ong, Pei Yun Hon, Jane Hawkey, Kathryn E. Holt, Tse Hsien Koh, Micky Lo Ngah Leong, Jocelyn Qi Min Teo, Thean Yen Tan, Mary Mah Lee Ng, Li Yang Hsu

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11 Citations (Scopus)

Abstract

We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were significant differences in terms of antibiotic susceptibility and genetic determinants of resistance in A. baumannii isolates that had developed polymyxin B resistance in vivo compared to isolates that had developed polymyxin B resistance in vitro.

Original languageEnglish
Pages (from-to)7899-7902
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes

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