Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in eμ-v-abl transgenic mice

R. C Andrew Symons, Mark J. Daly, Jane Fridlyand, Terence P. Speed, Wendy D. Cook, Steven Gerondakis, Alan W. Harris, Simon J. Foote

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27 Citations (Scopus)

Abstract

There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2,4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17.

Original languageEnglish
Pages (from-to)11299-11304
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number17
DOIs
Publication statusPublished - 20 Aug 2002
Externally publishedYes

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