Multiphase Flows in Pharmaceutical Applications

Z. B. Tong; R. Y. Yang; H. K. Chan; A. B. Yu

doi:10.1007/978-981-287-092-6_22

Multiphase Flows in Pharmaceutical Applications

Z. B. Tong, R. Y. Yang, H. K. Chan, A. B. Yu

Chemical & Biological Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

Abstract

Dry powder inhalers (DPI) have been widely used for drug delivery to the respiratory tract to treat disease such as asthma and cystic fibrosis. It is therefore important to improve their efficiency through better understanding of dispersion mechanisms of powders in devices. In this aspect, numerical modeling has been playing an increasingly important role. This chapter reviews the recent progress using computational fluid dynamics (CFD) and the discrete element method (DEM) to investigate the airflow and de-agglomeration in DPIs. In particular, with the coupled CFD and DEM approach, the models are able to generate detailed information at the particle scale, leading to improved and novel designs of next generations of DPI systems.

Original language	English
Title of host publication	Handbook of Multiphase Flow Science and Technology
Editors	Guan Heng Yeoh, Jyeshtharaj B. Joshi
Place of Publication	Singapore Singapore
Publisher	Springer
Chapter	21
Pages	749-772
Number of pages	24
Edition	1st
ISBN (Electronic)	9789812870926
ISBN (Print)	9789812870919
DOIs	https://doi.org/10.1007/978-981-287-092-6_22
Publication status	Published - 2023

Keywords

Aerosol drug delivery
Computational fluid dynamics
Discrete element method
Dry powder inhaler
Particle-scale modeling
Powder dispersion

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10.1007/978-981-287-092-6_22

Cite this

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title = "Multiphase Flows in Pharmaceutical Applications",

abstract = "Dry powder inhalers (DPI) have been widely used for drug delivery to the respiratory tract to treat disease such as asthma and cystic fibrosis. It is therefore important to improve their efficiency through better understanding of dispersion mechanisms of powders in devices. In this aspect, numerical modeling has been playing an increasingly important role. This chapter reviews the recent progress using computational fluid dynamics (CFD) and the discrete element method (DEM) to investigate the airflow and de-agglomeration in DPIs. In particular, with the coupled CFD and DEM approach, the models are able to generate detailed information at the particle scale, leading to improved and novel designs of next generations of DPI systems.",

keywords = "Aerosol drug delivery, Computational fluid dynamics, Discrete element method, Dry powder inhaler, Particle-scale modeling, Powder dispersion",

author = "Tong, {Z. B.} and Yang, {R. Y.} and Chan, {H. K.} and Yu, {A. B.}",

note = "Funding Information: Authors are grateful to the Australian Research Council (ARC) for the financial support. Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2023.",

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T1 - Multiphase Flows in Pharmaceutical Applications

AU - Tong, Z. B.

AU - Yang, R. Y.

AU - Chan, H. K.

AU - Yu, A. B.

N1 - Funding Information: Authors are grateful to the Australian Research Council (ARC) for the financial support. Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2023.

PY - 2023

Y1 - 2023

N2 - Dry powder inhalers (DPI) have been widely used for drug delivery to the respiratory tract to treat disease such as asthma and cystic fibrosis. It is therefore important to improve their efficiency through better understanding of dispersion mechanisms of powders in devices. In this aspect, numerical modeling has been playing an increasingly important role. This chapter reviews the recent progress using computational fluid dynamics (CFD) and the discrete element method (DEM) to investigate the airflow and de-agglomeration in DPIs. In particular, with the coupled CFD and DEM approach, the models are able to generate detailed information at the particle scale, leading to improved and novel designs of next generations of DPI systems.

AB - Dry powder inhalers (DPI) have been widely used for drug delivery to the respiratory tract to treat disease such as asthma and cystic fibrosis. It is therefore important to improve their efficiency through better understanding of dispersion mechanisms of powders in devices. In this aspect, numerical modeling has been playing an increasingly important role. This chapter reviews the recent progress using computational fluid dynamics (CFD) and the discrete element method (DEM) to investigate the airflow and de-agglomeration in DPIs. In particular, with the coupled CFD and DEM approach, the models are able to generate detailed information at the particle scale, leading to improved and novel designs of next generations of DPI systems.

KW - Aerosol drug delivery

KW - Computational fluid dynamics

KW - Discrete element method

KW - Dry powder inhaler

KW - Particle-scale modeling

KW - Powder dispersion

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A2 - Heng Yeoh, Guan

A2 - B. Joshi, Jyeshtharaj

PB - Springer

CY - Singapore Singapore

ER -

Multiphase Flows in Pharmaceutical Applications

Abstract

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