Multiparameter toxicity screening on a chip: Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells

Scott McCormick, Louise E. Smith, Amy M. Holmes, Ziqiu Tong, Enzo Lombi, Nicolas H. Voelcker, Craig Priest

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation.

Original languageEnglish
Article number044112
Number of pages8
JournalBiomicrofluidics
Volume13
Issue number4
DOIs
Publication statusPublished - 1 Jul 2019

Cite this

McCormick, Scott ; Smith, Louise E. ; Holmes, Amy M. ; Tong, Ziqiu ; Lombi, Enzo ; Voelcker, Nicolas H. ; Priest, Craig. / Multiparameter toxicity screening on a chip : Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells. In: Biomicrofluidics. 2019 ; Vol. 13, No. 4.
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Multiparameter toxicity screening on a chip : Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells. / McCormick, Scott; Smith, Louise E.; Holmes, Amy M.; Tong, Ziqiu; Lombi, Enzo; Voelcker, Nicolas H.; Priest, Craig.

In: Biomicrofluidics, Vol. 13, No. 4, 044112, 01.07.2019.

Research output: Contribution to journalArticleResearchpeer-review

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