Abstract
Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation.
| Original language | English |
|---|---|
| Article number | 044112 |
| Number of pages | 8 |
| Journal | Biomicrofluidics |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jul 2019 |
Cite this
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Multiparameter toxicity screening on a chip : Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells. / McCormick, Scott; Smith, Louise E.; Holmes, Amy M.; Tong, Ziqiu; Lombi, Enzo; Voelcker, Nicolas H.; Priest, Craig.
In: Biomicrofluidics, Vol. 13, No. 4, 044112, 01.07.2019.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Multiparameter toxicity screening on a chip
T2 - Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells
AU - McCormick, Scott
AU - Smith, Louise E.
AU - Holmes, Amy M.
AU - Tong, Ziqiu
AU - Lombi, Enzo
AU - Voelcker, Nicolas H.
AU - Priest, Craig
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation.
AB - Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation.
UR - http://www.scopus.com/inward/record.url?scp=85071577157&partnerID=8YFLogxK
U2 - 10.1063/1.5113729
DO - 10.1063/1.5113729
M3 - Article
VL - 13
JO - Biomicrofluidics
JF - Biomicrofluidics
SN - 1932-1058
IS - 4
M1 - 044112
ER -