Multiparameter toxicity screening on a chip: Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells

Scott McCormick; Louise E. Smith; Amy M. Holmes; Ziqiu Tong; Enzo Lombi; Nicolas H. Voelcker; Craig Priest

doi:10.1063/1.5113729

Multiparameter toxicity screening on a chip: Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells

Scott McCormick, Louise E. Smith, Amy M. Holmes, Ziqiu Tong, Enzo Lombi, Nicolas H. Voelcker, Craig Priest

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation.

Original language	English
Article number	044112
Number of pages	8
Journal	Biomicrofluidics
Volume	13
Issue number	4
DOIs	https://doi.org/10.1063/1.5113729
Publication status	Published - 1 Jul 2019

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10.1063/1.5113729

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Cite this

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abstract = "Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation.",

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Multiparameter toxicity screening on a chip : Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells. / McCormick, Scott; Smith, Louise E.; Holmes, Amy M.; Tong, Ziqiu; Lombi, Enzo; Voelcker, Nicolas H.; Priest, Craig.

In: Biomicrofluidics, Vol. 13, No. 4, 044112, 01.07.2019.

Research output: Contribution to journal › Article › Research › peer-review

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