Multiparameter Fluorescence-Activated Cell Sorting of Human Lymphatic Endothelial Cells

Theresa Connor, Nerida Sleebs, Zerina Lokmic-Tomkins

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Multiparameter fluorescence-activated cell sorting (FACS) procedure separates target cells from a total population of cells by using specific signatures that the target cell expresses on their cell surface. For human lymphatic endothelial cells (LECs) this relates to cell surface expression of the CD34LowCD31HighVEGFR-3HighPodoplaninHigh profile that permits their separation from blood vascular endothelial cells and other cells likely to be present in the digested tissue sample. In addition, FACS allows the evaluation of LEC size, volume, granularity, and purity at the time of sorting.

Original languageEnglish
Title of host publicationVEGF Signaling
Subtitle of host publicationMethods and Protocols
EditorsLorna R. Fiedler, Caroline Pellet-Many
Place of PublicationNew York NY USA
PublisherHumana Press
Chapter4
Pages47-59
Number of pages13
Edition2nd
ISBN (Electronic)9781071622179
ISBN (Print)9781071622162
DOIs
Publication statusPublished - 2022

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume2475
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Cell culture
  • Cell surface markers
  • FACS
  • Lymphatic endothelial cell

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