Multiomics medicine in oncology: Assessing effectiveness, cost-effectiveness and future research priorities for the molecularly unique individual

Brett Matthew Doble, Anthony H Harris, David M Thomas, Stephen B Fox, Paula Kate Lorgelly

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

The development of genomic technologies has ushered in the era of pharmacogenomics. However, discoveries and clinical use of targeted therapies are still in their infancy. A focus on monogenic pharmacogenetic traits may contribute to this lack of progress. Variation in drug response is likely a complex paradigm involving not only genomic factors but proteomic, metabolomic and epigenomic influences. The incorporation of these omics elements into pharmaceutical development and clinical decision-making will ultimately require the use of methods to determine clinical and economic value. Current methodologies and guidelines for determining clinical effectiveness and cost-effectiveness may have limited applicability to the increasingly personalized nature of omics treatment strategies. Using examples from oncology, this article argues for the adaptation and tailoring of three existing methods for ensuring development and clinical use of multiomics-guided therapies that are effective, safe and offer value for money.
Original languageEnglish
Pages (from-to)1405 - 1417
Number of pages13
JournalPharmacogenomics
Volume14
Issue number12
DOIs
Publication statusPublished - 2013

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