Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT

Benjamin H. Brinkmann, Richard A. Robb, Terence J. O’Brien, Michael K. O’Connor, Brian P. Mullan

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

5 Citations (Scopus)


Peri-ictal SPECT is a potentially powerful tool to study changes in regional cerebral blood flow during a partial seizure and to localize the seizure focus for pre-surgical evaluation. Recently we have developed and validated a method for co-registering and normalizing 3D interictal SPECT images to 3D ictal SPECT images and deriving a difference image co-registered to the patient's 3D MRI. This method has been shown to significantly improve clinical outcomes in surgery patients. In order to improve the method's sensitivity and specificity a number of enhancements have been added to the basic technique, including using voxel-based registration to better alignictal and interictal images, dual isotope (Tc-99m and 1-123) SPECT for effective tissue discrimination, and a custom software interface written to facilitate the entire process. We report results that show significant improvement over the original method, and we discuss future work which should continue to improve the method as a clinical tool.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings
PublisherSpringer-Verlag London Ltd.
Number of pages12
ISBN (Print)3540651365, 9783540651369
Publication statusPublished - 1 Jan 1998
Externally publishedYes
Event1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998 - Cambridge, United States of America
Duration: 11 Oct 199813 Oct 1998

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998
Country/TerritoryUnited States of America

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