Multiharmonic-generation biopsy of skin

Chi Kuang Sun; Cheng Chi Chen; Shi Wei Chu; Tsung Han Tsai; Yung Chih Chen; Bai Ling Lin

doi:10.1364/OL.28.002488

Multiharmonic-generation biopsy of skin

Chi Kuang Sun, Cheng Chi Chen, Shi Wei Chu, Tsung Han Tsai, Yung Chih Chen, Bai Ling Lin

Research output: Contribution to journal › Article › Research › peer-review

81 Citations (Scopus)

Abstract

Because it avoids the in-focus photodamage and phototoxicity problem of two-photon-fluorescence excitation, multiharmonic-generation biopsy based on a 1200-1300-nm light source could provide a truly noninvasive and highly penetrative optical sectioning of skin. We study multiharmonic-generation biopsy of fixed mouse skin. Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers.

Original language	English
Pages (from-to)	2488-2490
Number of pages	3
Journal	Optics Letters
Volume	28
Issue number	24
DOIs	https://doi.org/10.1364/OL.28.002488
Publication status	Published - 15 Dec 2003
Externally published	Yes

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10.1364/OL.28.002488

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AU - Chu, Shi Wei

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AU - Chen, Yung Chih

AU - Lin, Bai Ling

PY - 2003/12/15

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AB - Because it avoids the in-focus photodamage and phototoxicity problem of two-photon-fluorescence excitation, multiharmonic-generation biopsy based on a 1200-1300-nm light source could provide a truly noninvasive and highly penetrative optical sectioning of skin. We study multiharmonic-generation biopsy of fixed mouse skin. Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers.

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Multiharmonic-generation biopsy of skin

Abstract

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