Abstract
A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Methods, Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. Results, The gold nanoparticles helped to improve both transfection and Raman signal. Conclusions, This vector system can be effective for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.
Original language | English |
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Pages (from-to) | 664-678 |
Number of pages | 15 |
Journal | International Journal of Nanotechnology |
Volume | 8 |
Issue number | 8-9 |
DOIs | |
Publication status | Published - Jul 2011 |
Externally published | Yes |
Keywords
- Antisense oligodeoxynucleotides
- ASODNs
- GNPs
- Gold nanoparticles
- Single-walled carbon nanotubes
- SWNTs
- Transfection vector