Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan, Kristian Kempe, Thomas Michel Eric Bonnard, Jiwei Cui, Karen Maria Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina Kate Such, Karlheinz Peter, Christoph Eugen Hagemeyer, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
Original languageEnglish
Pages (from-to)5153-5157
Number of pages5
JournalAdvanced Materials
Volume27
Issue number35
DOIs
Publication statusPublished - 2015
Externally publishedYes

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