Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan, Kristian Kempe, Thomas Michel Eric Bonnard, Jiwei Cui, Karen Maria Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina Kate Such, Karlheinz Peter, Christoph Eugen Hagemeyer, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
Original languageEnglish
Pages (from-to)5153-5157
Number of pages5
JournalAdvanced Materials
Volume27
Issue number35
DOIs
Publication statusPublished - 2015
Externally publishedYes

Cite this

Gunawan, Sylvia T ; Kempe, Kristian ; Bonnard, Thomas Michel Eric ; Cui, Jiwei ; Alt, Karen Maria ; Law, Lok S ; Wang, Xiaowei ; Westein, Erik ; Such, Georgina Kate ; Peter, Karlheinz ; Hagemeyer, Christoph Eugen ; Caruso, Frank. / Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets. In: Advanced Materials. 2015 ; Vol. 27, No. 35. pp. 5153-5157.
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abstract = "Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.",
author = "Gunawan, {Sylvia T} and Kristian Kempe and Bonnard, {Thomas Michel Eric} and Jiwei Cui and Alt, {Karen Maria} and Law, {Lok S} and Xiaowei Wang and Erik Westein and Such, {Georgina Kate} and Karlheinz Peter and Hagemeyer, {Christoph Eugen} and Frank Caruso",
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Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets. / Gunawan, Sylvia T; Kempe, Kristian; Bonnard, Thomas Michel Eric; Cui, Jiwei; Alt, Karen Maria; Law, Lok S; Wang, Xiaowei; Westein, Erik; Such, Georgina Kate; Peter, Karlheinz; Hagemeyer, Christoph Eugen; Caruso, Frank.

In: Advanced Materials, Vol. 27, No. 35, 2015, p. 5153-5157.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Kempe, Kristian

AU - Bonnard, Thomas Michel Eric

AU - Cui, Jiwei

AU - Alt, Karen Maria

AU - Law, Lok S

AU - Wang, Xiaowei

AU - Westein, Erik

AU - Such, Georgina Kate

AU - Peter, Karlheinz

AU - Hagemeyer, Christoph Eugen

AU - Caruso, Frank

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AB - Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

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DO - 10.1002/adma.201502243

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JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

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