Multifunctional nanoworms and nanorods through a one-step aqueous dispersion polymerization

Z. Jia, Valentin A. Bobrin, Nghia Truong Phuoc, Marianne Gillard, Michael J Monteiro

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)


Producing synthetic soft worm and rod structures with multiple chemical functionalities on the surface would provide potential utility in drug delivery, nanoreactors, tissue engineering, diagnostics, rheology modifiers, enzyme mimics, and many other applications. Here, we have synthesized multifunctional worms and rods directly in water using a one-step reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization at high weight fractions of polymer (>10 wt %). The chain-end functionalities included alkyne, pyridyl disulfide, dopamine, β-thiolactone, and biotin groups. These groups could further be converted or coupled with biomolecules or polymers. We further demonstrated a nanorod colorimetric system with good control over the attachment of fluorescent probes.
Original languageEnglish
Pages (from-to)5824-5827
Number of pages4
JournalJournal of the American Chemical Society
Issue number16
Publication statusPublished - 23 Apr 2014
Externally publishedYes


  • Dispersions
  • Drug delivery
  • Nanorods
  • Polymerization
  • Tissue engineering
  • Aqueous dispersion polymerization
  • Chemical functionality
  • Dispersion polymerization
  • Fluorescent probes
  • Potential utility
  • Pyridyl disulfide
  • Reversible addition fragmentation chain transfer (RAFT)
  • Rheology modifiers
  • Polymers
  • alkyne
  • biotin
  • disulfide
  • dopamine
  • fluorescent dye
  • nanoparticle
  • nanorod
  • nanoworm
  • polymer
  • pyridine derivative
  • thiolactone
  • unclassified drug
  • acrylic acid resin
  • nanotube
  • poly-N-isopropylacrylamide
  • water
  • aqueous solution
  • article
  • dispersion
  • emulsion
  • fragmentation reaction
  • molecular weight
  • polymerization
  • reversible addition fragmentation chain transfer
  • stoichiometry
  • ultrasound
  • chemical structure
  • chemistry
  • conformation
  • temperature
  • Acrylic Resins
  • Models, Molecular
  • Molecular Conformation
  • Nanotubes
  • Temperature
  • Water

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