Multifaceted Role of IRAK-M in the Promotion of Colon Carcinogenesis via Barrier Dysfunction and STAT3 Oncoprotein Stabilization in Tumors

Research output: Contribution to journalShort SurveyOtherpeer-review

3 Citations (Scopus)


Dysregulated interactions between the host immune system and gut microbiota can underpin inflammation, leading to colorectal cancer (CRC). In this issue of Cancer Cell, Kesselring et al. reveal a bimodal role of the TLR/IL-1R-signaling negative regulator, IRAK-M, in promoting tumoral microbial colonization and STAT3 oncoprotein stabilization during CRC.

Original languageEnglish
Pages (from-to)615-617
Number of pages3
JournalCancer Cell
Issue number5
Publication statusPublished - 9 May 2016

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