Multidrug-resistant CTX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog

Meire M. Silva, Miriam R. Fernandes, Fábio P. Sellera, Louise Cerdeira, Lylian K.G. Medeiros, Felício Garino, Sérgio S. Azevedo, Nilton Lincopan

Research output: Contribution to journalArticleOtherpeer-review

14 Citations (Scopus)

Abstract

Extended spectrum β-lactamase (ESBL)-producing bacterial infections in veterinary medicine are a clinical and epidemiological challenge. We report a case of CTX-M-15-producing Klebsiella pneumoniae infection followed by persistent colonization, in a dog presenting with bilateral purulent nasal discharge and dyspnea. In this regard, 5 broad-spectrum cephalosporin-resistant K. pneumoniae isolates were recovered from infection and surveillance cultures, collected during 1 year and eight months study. Genomic analysis of a representative clone of K. pneumoniae (KpPB76) revealed the presence of the human-associated lineage ST231, whereas resistome data confirmed the presence of genes conferring resistance to aminoglycosides, β-lactams, fluoroquinolones, fosfomycin, phenicols, sulfonamides, tetracyclines and trimethoprim. In the absence of therapeutic options, meropenem therapy was used, contributing to the control of infection during persistent carriage of K. pneumoniae CTX-M-15/ST231. Persistent colonization of companion animals with ESBL-producing bacteria could be result from a variety of situations, including multi introduction from the owner or household family members to pets, or from environmental exposure; whereas colonized animals may serve as an important source for the spread of ESBL-producing strains in the human-animal interface.

Original languageEnglish
Pages (from-to)259-261
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume92
Issue number3
DOIs
Publication statusPublished - Nov 2018
Externally publishedYes

Keywords

  • Carbapenems
  • Companion animal
  • ESBL
  • Pets

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