Multidiagnostic evaluation of prolactin response to haloperidol challenge in schizophrenia: Maximal blunting in Kraepelinian patients

Nicholas A. Keks, Dean P. McKenzie, Lee Hun Low, Patrick D. McGorry, Christine Hill, Jayashri Kulkarni, Bruce S. Singh, David L. Copolov

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We have previously reported that prolactin (PRL) responses to haloperidol 0.5 mg IV were blunted in subjects characterized by several diagnostic systems of schizophrenia compared to controls (Keks et al 1990). However, an attempt to find a diagnostic system most different from controls was unsuccessful due to inherent difficulties in the statistical analysis of multidiagnostic data. In this paper we present new methodologies. A test for differences in dependent correlations demonstrated that most of the variance in stimulated PRL was accounted for by Kraepelinian, and least by Schneiderian and M. Bleulerian, schizophrenias (p < 0.001). The main symptomatic difference between nonKraepelinian and Kraepelinian patients was the presence of association disturbance and feelings of passivity. Patients with both symptoms had a lower stimulated PRL than controls. Further findings and possible implications are discussed.

Original languageEnglish
Pages (from-to)426-437
Number of pages12
JournalBiological Psychiatry
Issue number5
Publication statusPublished - 1 Sept 1992

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