Abstract
We created the Ontology of Craniofacial Development and Malformation (OCDM) [1] to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and midface hypoplasia. Animal models are used to support human studies and so we built multi-species ontologies that would allow for cross-species correlation of anatomical information. For this purpose we first developed and enhanced the craniofacial component of the human musculoskeletal system in the Foundational Model of Anatomy Ontology (FMA)[2], and then imported this component, which we call the Craniofacial Human Ontology (CHO), into the OCDM. The CHO was then used as a template to create the anatomy for the mouse, the Craniofacial Mouse Ontology (CMO) as well as for the zebrafish, the Craniofacial Zebrafish Ontology (CZO).
Original language | English |
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Number of pages | 2 |
Publication status | Published - 2016 |
Externally published | Yes |
Event | International Conference on Biological Ontology and BioCreative 2016 - Oregon State University, Corvallis, United States of America Duration: 1 Aug 2016 → 4 Aug 2016 Conference number: 7 http://icbo2016.cgrb.oregonstate.edu/ |
Conference
Conference | International Conference on Biological Ontology and BioCreative 2016 |
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Abbreviated title | ICBO-BioCreative 2016 |
Country/Territory | United States of America |
City | Corvallis |
Period | 1/08/16 → 4/08/16 |
Internet address |
Keywords
- Craniofacial congenital abnormalities
- FaceBase Consortium
- Foundational model of anatomy
- Ontology of craniofacial development and malformation