Multi-scale interaction of particulate flow and the artery wall

I. Halliday; M. Atherton; C. M. Care; M. W. Collins; D. Evans; P. C. Evans; D. R. Hose; A. W. Khir; C. S. König; R. Krams; P. V. Lawford; S. V. Lishchuk; G. Pontrelli; V. Ridger; T. J. Spencer; Y. Ventikos; D. C. Walker; P. N. Watton

doi:10.1016/j.medengphy.2010.09.007

Multi-scale interaction of particulate flow and the artery wall

I. Halliday, M. Atherton, C. M. Care, M. W. Collins, D. Evans, P. C. Evans, D. R. Hose, A. W. Khir, C. S. König, R. Krams, P. V. Lawford, S. V. Lishchuk, G. Pontrelli, V. Ridger, T. J. Spencer, Y. Ventikos, D. C. Walker, P. N. Watton

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.

Original language	English
Pages (from-to)	840-848
Number of pages	9
Journal	Medical Engineering and Physics
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.medengphy.2010.09.007
Publication status	Published - Sept 2011
Externally published	Yes

Keywords

Endothelium
Glycocalyx
Microcirculation
Multi-scale
Wall shear stress

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10.1016/j.medengphy.2010.09.007

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Halliday, I., Atherton, M., Care, C. M., Collins, M. W., Evans, D., Evans, P. C., Hose, D. R., Khir, A. W., König, C. S., Krams, R., Lawford, P. V., Lishchuk, S. V., Pontrelli, G., Ridger, V., Spencer, T. J., Ventikos, Y., Walker, D. C., & Watton, P. N. (2011). Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33(7), 840-848. https://doi.org/10.1016/j.medengphy.2010.09.007

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title = "Multi-scale interaction of particulate flow and the artery wall",

abstract = "We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.",

keywords = "Endothelium, Glycocalyx, Microcirculation, Multi-scale, Wall shear stress",

author = "I. Halliday and M. Atherton and Care, {C. M.} and Collins, {M. W.} and D. Evans and Evans, {P. C.} and Hose, {D. R.} and Khir, {A. W.} and K{\"o}nig, {C. S.} and R. Krams and Lawford, {P. V.} and Lishchuk, {S. V.} and G. Pontrelli and V. Ridger and Spencer, {T. J.} and Y. Ventikos and Walker, {D. C.} and Watton, {P. N.}",

year = "2011",

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doi = "10.1016/j.medengphy.2010.09.007",

language = "English",

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Halliday, I, Atherton, M, Care, CM, Collins, MW, Evans, D, Evans, PC, Hose, DR, Khir, AW, König, CS, Krams, R, Lawford, PV, Lishchuk, SV, Pontrelli, G, Ridger, V, Spencer, TJ, Ventikos, Y, Walker, DC & Watton, PN 2011, 'Multi-scale interaction of particulate flow and the artery wall', Medical Engineering and Physics, vol. 33, no. 7, pp. 840-848. https://doi.org/10.1016/j.medengphy.2010.09.007

TY - JOUR

T1 - Multi-scale interaction of particulate flow and the artery wall

AU - Halliday, I.

AU - Atherton, M.

AU - Care, C. M.

AU - Collins, M. W.

AU - Evans, D.

AU - Evans, P. C.

AU - Hose, D. R.

AU - Khir, A. W.

AU - König, C. S.

AU - Krams, R.

AU - Lawford, P. V.

AU - Lishchuk, S. V.

AU - Pontrelli, G.

AU - Ridger, V.

AU - Spencer, T. J.

AU - Ventikos, Y.

AU - Walker, D. C.

AU - Watton, P. N.

PY - 2011/9

Y1 - 2011/9

N2 - We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.

AB - We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.

KW - Endothelium

KW - Glycocalyx

KW - Microcirculation

KW - Multi-scale

KW - Wall shear stress

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DO - 10.1016/j.medengphy.2010.09.007

M3 - Article

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AN - SCOPUS:79961024583

SN - 1350-4533

VL - 33

SP - 840

EP - 848

JO - Medical Engineering and Physics

JF - Medical Engineering and Physics

IS - 7

ER -

Multi-scale interaction of particulate flow and the artery wall

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Keywords

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