Multi-column trajectory to advanced methods in comprehensive two-dimensional gas chromatography

Yada Nolvachai, Chadin Kulsing, Khan M Sharif, Yong Foo Wong, Sung Tong Chin, Blagoj Mitrevski, Philip Marriott

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)


Comprehensive two-dimensional gas chromatography (GC×GC) and multidimensional GC (MDGC) offer high performance separation capability towards multi-component samples, and improved sample characterisation. Recent advances, particularly with new GC×GC methodologies, which apply additional columns to GC×GC, along with hyphenation with mass spectrometry, potentially have a tremendous impact on the analysis of various applications such as food, petrochemicals, fragrances, drugs and environmental samples. The present review highlights the new experimental designs in GC×GC coupled with MDGC to offer significant changes in operational performance, and applications of these technologies which have been developed since 2000.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalTrAC - Trends in Analytical Chemistry
Publication statusPublished - 1 Sept 2018


  • Column switching
  • Dual parallel GC×GC
  • Higher dimensional separation
  • Hybrid GC×GC
  • Hybrid MDGC
  • Pressure tuning

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