Mucosal immune responses following intestinal nematode infection

C. Zaph, P. J. Cooper, N. L. Harris

Research output: Contribution to journalReview ArticleOtherpeer-review

29 Citations (Scopus)


In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1–2 years) [1]. Although these organisms have been eradicated to a large extent within westernized human populations, those living within rural areas of developing countries continue to suffer from high infection rates. Indeed, recent estimates indicate that approximately 2·5 billion people worldwide, mainly children, currently suffer from infection with intestinal helminths (also known as geohelminths and soil-transmitted helminths) [1, 2]. Paradoxically, the eradication of helminths is thought to contribute to the increased incidence of autoimmune diseases and allergy observed in developed countries. In this review, we will summarize our current understanding of host–helminth interactions at the mucosal surface that result in parasite expulsion or permit the establishment of chronic infections with luminal dwelling adult worms. We will also provide insight into the adaptive immune mechanisms that provide immune protection against re-infection with helminth larvae, a process that is likely to be key to the future development of successful vaccination strategies. Lastly, the contribution of helminths to immune modulation and particularly to the treatment of allergy and inflammatory bowel disease will be discussed.
Original languageEnglish
Pages (from-to)439-452
Number of pages14
JournalParasite Immunology
Issue number9
Publication statusPublished - 8 Sep 2014
Externally publishedYes


  • Geohelminth
  • Immune-expulsion
  • Intestinal helminth
  • Mucosal immunity
  • Nematode
  • Type 2 immunity

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