Mucoadhesive microspheres of glutaraldehyde crosslinked mucilage of Isabgol husk for sustained release of gliclazide

Vipin Kumar Sharma, Prince Prashant Sharma, Bhaskar Mazumder, Aseem Bhatnagar, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Mucoadhesive microspheres have their own significant amongst the various sustained release drug delivery systems. The prolonged residence time of these delivery devices at drug absorption site results in steep concentration gradient and enhanced bioavailability. In this study, the mucilage of Isabgol husk was applied as polymeric backbone to develop gliclazide loaded microspheres by crosslinking with glutaraldehyde. The formulations were studied for surface morphology, swelling behavior, particle size, in vitro release, release kinetics, in vitro mucoadhesion and gamma scintigraphy in rabbits. The release of gliclazide from microspheres was controlled by swelling of crosslinked microspheres followed by diffusion. Gamma scintigraphic images acquired for microspheres retention in gastrointestinal track of rabbits indicated the residence of formulation upto 24 h after oral administration. Gliclazide retained its integrity in polymeric matrix of microspheres as observed by Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffractometry. The sustained release of gliclazide and prolonged retention of microspheres in gastrointestinal track disclosed the rationality of mucoadhesive Isabgol husk microspheres in controlling the hyperglycemia in diabetes.

Original languageEnglish
Pages (from-to)1420-1449
Number of pages30
JournalJournal of Biomaterials Science, Polymer Edition
Volume32
Issue number11
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Bioadhesion
  • biodegradation
  • crosslinking
  • optimization

Cite this