MRI correlates of general intelligence in neurotypical adults

Charles B. Malpas, Sila Genc, Michael M. Saling, Dennis Velakoulis, Patricia M. Desmond, Terence J. O'Brien

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17 Citations (Scopus)


There is growing interest in the neurobiological substrate of general intelligence. Psychometric estimates of general intelligence are reduced in a range of neurological disorders, leading to practical application as sensitive, but non-specific, markers of cerebral disorder. This study examined estimates of general intelligence in neurotypical adults using diffusion tensor imaging and resting-state functional connectivity analysis. General intelligence was related to white matter organisation across multiple brain regions, confirming previous work in older healthy adults. We also found that variation in general intelligence was related to a large functional sub-network involving all cortical lobes of the brain. These findings confirm that individual variance in general intelligence is related to diffusely represented brain networks.

Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalJournal of Clinical Neuroscience
Publication statusPublished - 1 Feb 2016
Externally publishedYes


  • Diffusion MRI
  • Functional connectivity
  • General intelligence
  • IQ
  • Resting state
  • White matter

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