MRI compatible electrodes for the induction of amygdala kindling in rats

Bianca Jupp, John P. Williams, Yasvir A. Tesiram, Milosh Vosmansky, Terence J. O'Brien

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

The rat electrical kindling model has been widely utilized in epilepsy research. This study aimed to identify the optimum "MRI compatible" bipolar stimulating and recording electrodes to enable serial MRI acquisition in this model. Two types of custom-made electrodes (gold and carbon) were compared with commercial platinum-iridium alloy electrodes for suitability based on size, effect on image quality and kindling induction. The custom-made gold electrodes, based on these parameters, were found to be most suitable. These electrodes enable the study of epileptogenesis utilizing MRI in this model of temporal lobe epilepsy (TLE).

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalJournal of Neuroscience Methods
Volume155
Issue number1
DOIs
Publication statusPublished - 15 Jul 2006
Externally publishedYes

Keywords

  • Electrodes
  • Kindling
  • MRI
  • Temporal lobe epilepsy

Cite this