Mouse models for gastric cancer: Matching models to biological questions

Ashleigh R Poh, Robert J.J. O'Donoghue, Matthias Ernst, Tracy L Putoczki

Research output: Contribution to journalReview ArticleOtherpeer-review

17 Citations (Scopus)

Abstract

Gastric cancer is the third leading cause of cancer-related mortality worldwide. This is in part due to the asymptomatic nature of the disease, which often results in late-stage diagnosis, at which point there are limited treatment options. Even when treated successfully, gastric cancer patients have a high risk of tumor recurrence and acquired drug resistance. It is vital to gain a better understanding of the molecular mechanisms underlying gastric cancer pathogenesis to facilitate the design of new-targeted therapies that may improve patient survival. A number of chemically and genetically engineered mouse models of gastric cancer have provided significant insight into the contribution of genetic and environmental factors to disease onset and progression. This review outlines the strengths and limitations of current mouse models of gastric cancer and their relevance to the pre-clinical development of new therapeutics.

Original languageEnglish
Pages (from-to)1257-1272
Number of pages16
JournalJournal of Gastroenterology and Hepatology
Volume31
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Keywords

  • diffuse gastric cancer
  • Helicobacter pylori
  • intestinal-type gastric cancer
  • mouse model

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