Motor neuron disease: A chemical perspective

Laura K. Wood, Steven J. Langford

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)


This Perspective provides a background to the pathogenesis of neurodegenerative disease and specifically amyotrophic lateral sclerosis (ALS) and gives an overview of the many pathways, both genetically inheritable and sporadic, that may lead to the premature activation of apoptotic pathways in neurons, as well as current and proposed approaches toward interrupting these pathways.

Original languageEnglish
Pages (from-to)6316-6331
Number of pages16
JournalJournal of Medicinal Chemistry
Issue number15
Publication statusPublished - 14 Aug 2014

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