TY - JOUR
T1 - Motor and non-motor inhibition in the Go/NoGo task: an ERP and fMRI study
AU - Smith, Janette L
AU - Jamadar, Sharna
AU - Provost, Alexander L
AU - Michie, Patricia
PY - 2013
Y1 - 2013
N2 - The contribution of movement-related activity to Go/NoGo ERP differences has been debated for 25 years. In this study, we examined ERP and fMRI measures of activity in twenty adults performing non-motor (count) and motor (right-handed button press) trials of the Go/NoGo task. Task performance was highly accurate and similar in the ERP and fMRI environments. No significant task-related effects were observed for the N2 component; however, we observed a substantial increase in positivity for Press NoGo compared to Count NoGo trials. The fMRI results also revealed significant deactivations for Press NoGo relative to Count NoGo trials in several left-lateralised motor-related areas, including the inferior frontal gyrus, precentral gyrus and supplementary motor area. Together, the results indicate that the P3 NoGo > Go effect in motor tasks is caused not by movement-related negativity on Go trials but by inhibition-related positivity on NoGo trials, and that this is associated with deactivation of motor areas involved in the Go response.
Highlights
► Motor and non-motor Go/NoGo tasks with ERP and fMRI in separate sessions. ► Increased P3 for Press NoGo compared to Count NoGo. ► Significant deactivation of motor regions for Press NoGo relative to Count NoGo. ► Press NoGo involves an active inhibition process, not just the absence of movement.
AB - The contribution of movement-related activity to Go/NoGo ERP differences has been debated for 25 years. In this study, we examined ERP and fMRI measures of activity in twenty adults performing non-motor (count) and motor (right-handed button press) trials of the Go/NoGo task. Task performance was highly accurate and similar in the ERP and fMRI environments. No significant task-related effects were observed for the N2 component; however, we observed a substantial increase in positivity for Press NoGo compared to Count NoGo trials. The fMRI results also revealed significant deactivations for Press NoGo relative to Count NoGo trials in several left-lateralised motor-related areas, including the inferior frontal gyrus, precentral gyrus and supplementary motor area. Together, the results indicate that the P3 NoGo > Go effect in motor tasks is caused not by movement-related negativity on Go trials but by inhibition-related positivity on NoGo trials, and that this is associated with deactivation of motor areas involved in the Go response.
Highlights
► Motor and non-motor Go/NoGo tasks with ERP and fMRI in separate sessions. ► Increased P3 for Press NoGo compared to Count NoGo. ► Significant deactivation of motor regions for Press NoGo relative to Count NoGo. ► Press NoGo involves an active inhibition process, not just the absence of movement.
UR - http://ac.els-cdn.com/S0167876012005508/1-s2.0-S0167876012005508-main.pdf?_tid=634e5d9e-2705-11e3-a46c-00000aacb35e&acdnat=1380239164_d1e76b4f4e19bda6
U2 - 10.1016/j.ijpsycho.2012.07.185
DO - 10.1016/j.ijpsycho.2012.07.185
M3 - Article
VL - 87
SP - 244
EP - 253
JO - International Journal of Psychophysiology
JF - International Journal of Psychophysiology
SN - 0167-8760
IS - 3
ER -