Mother’s curse and indirect genetic effects: Do males matter to mitochondrial genome evolution?

Thomas A. Keaney, Heidi W.S. Wong, Damian K. Dowling, Therésa M. Jones, Luke Holman

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Maternal inheritance of mitochondrial DNA (mtDNA) was originally thought to prevent any response to selection on male phenotypic variation attributable to mtDNA, resulting in a male-biased mtDNA mutation load (“mother's curse”). However, the theory underpinning this claim implicitly assumes that a male's mtDNA has no effect on the fitness of females he comes into contact with. If such “mitochondrially encoded indirect genetics effects” (mtIGEs) do in fact exist, and there is relatedness between the mitochondrial genomes of interacting males and females, male mtDNA-encoded traits can undergo adaptation after all. We tested this possibility using strains of Drosophila melanogaster that differ in their mtDNA. Our experiments indicate that female fitness is influenced by the mtDNA carried by males that the females encounter, which could plausibly allow the mitochondrial genome to evolve via kin selection. We argue that mtIGEs are probably common, and that this might ameliorate or exacerbate mother's curse.

Original languageEnglish
Pages (from-to)189-201
Number of pages13
JournalJournal of Evolutionary Biology
Volume33
Issue number2
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • indirect genetic effects
  • interacting phenotypes
  • kin selection
  • mtDNA
  • mutation load
  • sexual conflict

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