Morphology of the corpus callosum at different stages of schizophrenia: Cross-sectional study in first-episode and chronic illness

Background: The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness. Aims: To investigate the size and shape of the corpus callosum in a large sample of people with first-episode and established schizophrenia. Method: Callosal size and shape were determined using high-resolution magnetic resonance imaging on 76 patients with first-episode schizophrenia-spectrum disorders, 86 patients with established schizophrenia and 55 healthy participants. Results: There were no significant differences in total area across groups. Reductions in callosal width were seen in the region of the anterior genu in first-episode disorder (P