Morphological development of the mammalian kidney

Karen M. Moritz, Marelyn Wintour-Coghlan, M. Jane Black, John F. Bertram, Georgina Caruana

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

7 Citations (Scopus)

Abstract

In mammals, three pairs of excretory organs form from the intermediate mesoderm in a cranial to caudal direction. These are the pronephroi, mesonephroi and metanephroi, respectively. The pronephroi and mesonephroi are transient organs, but their existence is required for the development of the metanephroi or permanent kidneys. The development of these three excretory organs is shown diagrammatically in Fig. 1. The pronephros is the obligatory precursor of the adult renal system. Pronephroi begin to form at 21-22 days post-coitum (dpc) in humans and 8 dpc in the mouse (Woolf et al. 2003). The pronephros develops as a nephrotome containing a nephrocoel (cavity) which is in direct communication with the adjacent intraembryonic coelom by a short peritoneal funnel. The vascularized filtration unit (glomus) projects into the nephrocoel but filters directly into the coelom. The wall of the nephrotome opposite the peritoneal funnel gives rise to a tubule which joins the nephrocoel to the pronephric duct (future Wolffian duct) via the pronephric tubules. The ciliated cells in the nephrotome move the fluid into pronephric tubules by ciliary action, from where some reabsorption can occur into a surrounding blood sinus. The pronephric duct ends in the cloaca. The number of pronephric tubules varies between different animals and species and in ungulates these tubules are represented by a giant glomerulus in the head of the mesonephros (Vize et al. 1997; reviewed in Vize et al. 2003). In general, amphibians and fish have well-developed functional pronephroi that persist throughout the life of the organism and regulate water and solute balance as well as blood pH (Drummond and Majumdar 2003). However, amniotes have rudimentary, transient pronephroi which are thought to have no renal function, although this has not been tested. Many of the same genes (Pax2, Pax8, Gata3, Lim1, FGF8, Six1, WT-1 and Wnt-4) are expressed in the pronephros as in the later forms of renal tissue (Vize et al. 1997; Hensey et al. 2002; Chan and Asshima 2006; Bouchard et al. 2002; Grote et al. 2006).

Original languageEnglish
Title of host publicationFactors Influencing Mammalian Kidney Development
Subtitle of host publicationImplications for Health in Adult Life
Pages1-9
Number of pages9
DOIs
Publication statusPublished - 3 Jun 2008

Publication series

NameAdvances in Anatomy Embryology and Cell Biology
Volume196
ISSN (Print)0301-5556

Cite this

Moritz, K. M., Wintour-Coghlan, M., Black, M. J., Bertram, J. F., & Caruana, G. (2008). Morphological development of the mammalian kidney. In Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life (pp. 1-9). (Advances in Anatomy Embryology and Cell Biology; Vol. 196). https://doi.org/10.1007/978-3-540-77768-7_2
Moritz, Karen M. ; Wintour-Coghlan, Marelyn ; Black, M. Jane ; Bertram, John F. ; Caruana, Georgina. / Morphological development of the mammalian kidney. Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. 2008. pp. 1-9 (Advances in Anatomy Embryology and Cell Biology).
@inbook{6bcdaa32d92146258d82c14a2c845631,
title = "Morphological development of the mammalian kidney",
abstract = "In mammals, three pairs of excretory organs form from the intermediate mesoderm in a cranial to caudal direction. These are the pronephroi, mesonephroi and metanephroi, respectively. The pronephroi and mesonephroi are transient organs, but their existence is required for the development of the metanephroi or permanent kidneys. The development of these three excretory organs is shown diagrammatically in Fig. 1. The pronephros is the obligatory precursor of the adult renal system. Pronephroi begin to form at 21-22 days post-coitum (dpc) in humans and 8 dpc in the mouse (Woolf et al. 2003). The pronephros develops as a nephrotome containing a nephrocoel (cavity) which is in direct communication with the adjacent intraembryonic coelom by a short peritoneal funnel. The vascularized filtration unit (glomus) projects into the nephrocoel but filters directly into the coelom. The wall of the nephrotome opposite the peritoneal funnel gives rise to a tubule which joins the nephrocoel to the pronephric duct (future Wolffian duct) via the pronephric tubules. The ciliated cells in the nephrotome move the fluid into pronephric tubules by ciliary action, from where some reabsorption can occur into a surrounding blood sinus. The pronephric duct ends in the cloaca. The number of pronephric tubules varies between different animals and species and in ungulates these tubules are represented by a giant glomerulus in the head of the mesonephros (Vize et al. 1997; reviewed in Vize et al. 2003). In general, amphibians and fish have well-developed functional pronephroi that persist throughout the life of the organism and regulate water and solute balance as well as blood pH (Drummond and Majumdar 2003). However, amniotes have rudimentary, transient pronephroi which are thought to have no renal function, although this has not been tested. Many of the same genes (Pax2, Pax8, Gata3, Lim1, FGF8, Six1, WT-1 and Wnt-4) are expressed in the pronephros as in the later forms of renal tissue (Vize et al. 1997; Hensey et al. 2002; Chan and Asshima 2006; Bouchard et al. 2002; Grote et al. 2006).",
author = "Moritz, {Karen M.} and Marelyn Wintour-Coghlan and Black, {M. Jane} and Bertram, {John F.} and Georgina Caruana",
year = "2008",
month = "6",
day = "3",
doi = "10.1007/978-3-540-77768-7_2",
language = "English",
isbn = "9783540777670",
series = "Advances in Anatomy Embryology and Cell Biology",
pages = "1--9",
booktitle = "Factors Influencing Mammalian Kidney Development",

}

Moritz, KM, Wintour-Coghlan, M, Black, MJ, Bertram, JF & Caruana, G 2008, Morphological development of the mammalian kidney. in Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. Advances in Anatomy Embryology and Cell Biology, vol. 196, pp. 1-9. https://doi.org/10.1007/978-3-540-77768-7_2

Morphological development of the mammalian kidney. / Moritz, Karen M.; Wintour-Coghlan, Marelyn; Black, M. Jane; Bertram, John F.; Caruana, Georgina.

Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. 2008. p. 1-9 (Advances in Anatomy Embryology and Cell Biology; Vol. 196).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

TY - CHAP

T1 - Morphological development of the mammalian kidney

AU - Moritz, Karen M.

AU - Wintour-Coghlan, Marelyn

AU - Black, M. Jane

AU - Bertram, John F.

AU - Caruana, Georgina

PY - 2008/6/3

Y1 - 2008/6/3

N2 - In mammals, three pairs of excretory organs form from the intermediate mesoderm in a cranial to caudal direction. These are the pronephroi, mesonephroi and metanephroi, respectively. The pronephroi and mesonephroi are transient organs, but their existence is required for the development of the metanephroi or permanent kidneys. The development of these three excretory organs is shown diagrammatically in Fig. 1. The pronephros is the obligatory precursor of the adult renal system. Pronephroi begin to form at 21-22 days post-coitum (dpc) in humans and 8 dpc in the mouse (Woolf et al. 2003). The pronephros develops as a nephrotome containing a nephrocoel (cavity) which is in direct communication with the adjacent intraembryonic coelom by a short peritoneal funnel. The vascularized filtration unit (glomus) projects into the nephrocoel but filters directly into the coelom. The wall of the nephrotome opposite the peritoneal funnel gives rise to a tubule which joins the nephrocoel to the pronephric duct (future Wolffian duct) via the pronephric tubules. The ciliated cells in the nephrotome move the fluid into pronephric tubules by ciliary action, from where some reabsorption can occur into a surrounding blood sinus. The pronephric duct ends in the cloaca. The number of pronephric tubules varies between different animals and species and in ungulates these tubules are represented by a giant glomerulus in the head of the mesonephros (Vize et al. 1997; reviewed in Vize et al. 2003). In general, amphibians and fish have well-developed functional pronephroi that persist throughout the life of the organism and regulate water and solute balance as well as blood pH (Drummond and Majumdar 2003). However, amniotes have rudimentary, transient pronephroi which are thought to have no renal function, although this has not been tested. Many of the same genes (Pax2, Pax8, Gata3, Lim1, FGF8, Six1, WT-1 and Wnt-4) are expressed in the pronephros as in the later forms of renal tissue (Vize et al. 1997; Hensey et al. 2002; Chan and Asshima 2006; Bouchard et al. 2002; Grote et al. 2006).

AB - In mammals, three pairs of excretory organs form from the intermediate mesoderm in a cranial to caudal direction. These are the pronephroi, mesonephroi and metanephroi, respectively. The pronephroi and mesonephroi are transient organs, but their existence is required for the development of the metanephroi or permanent kidneys. The development of these three excretory organs is shown diagrammatically in Fig. 1. The pronephros is the obligatory precursor of the adult renal system. Pronephroi begin to form at 21-22 days post-coitum (dpc) in humans and 8 dpc in the mouse (Woolf et al. 2003). The pronephros develops as a nephrotome containing a nephrocoel (cavity) which is in direct communication with the adjacent intraembryonic coelom by a short peritoneal funnel. The vascularized filtration unit (glomus) projects into the nephrocoel but filters directly into the coelom. The wall of the nephrotome opposite the peritoneal funnel gives rise to a tubule which joins the nephrocoel to the pronephric duct (future Wolffian duct) via the pronephric tubules. The ciliated cells in the nephrotome move the fluid into pronephric tubules by ciliary action, from where some reabsorption can occur into a surrounding blood sinus. The pronephric duct ends in the cloaca. The number of pronephric tubules varies between different animals and species and in ungulates these tubules are represented by a giant glomerulus in the head of the mesonephros (Vize et al. 1997; reviewed in Vize et al. 2003). In general, amphibians and fish have well-developed functional pronephroi that persist throughout the life of the organism and regulate water and solute balance as well as blood pH (Drummond and Majumdar 2003). However, amniotes have rudimentary, transient pronephroi which are thought to have no renal function, although this has not been tested. Many of the same genes (Pax2, Pax8, Gata3, Lim1, FGF8, Six1, WT-1 and Wnt-4) are expressed in the pronephros as in the later forms of renal tissue (Vize et al. 1997; Hensey et al. 2002; Chan and Asshima 2006; Bouchard et al. 2002; Grote et al. 2006).

UR - http://www.scopus.com/inward/record.url?scp=44449122247&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-77768-7_2

DO - 10.1007/978-3-540-77768-7_2

M3 - Chapter (Book)

SN - 9783540777670

T3 - Advances in Anatomy Embryology and Cell Biology

SP - 1

EP - 9

BT - Factors Influencing Mammalian Kidney Development

ER -

Moritz KM, Wintour-Coghlan M, Black MJ, Bertram JF, Caruana G. Morphological development of the mammalian kidney. In Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. 2008. p. 1-9. (Advances in Anatomy Embryology and Cell Biology). https://doi.org/10.1007/978-3-540-77768-7_2