Morphogenesis of the rat pre-implantation embryo and environmental toxicant

Karla J. Hutt, Zhanquan Shi, David F. Albertini, Brian K. Petroff

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Environmental toxicants, whose actions are often mediated through the aryl hydrocarbon receptor (AhR) pathway, pose risks to the health and well-being of exposed species, including humans. Of particular concern are exposures during the earliest stages of development that while failing to abrogate embryogenesis, may have long term effects on newborns or adults. The purpose of this study was to evaluate the effect of maternal exposure to the AhR-specific ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development of rat pre-implantation embryos with respect to nuclear and cytoskeletal architecture and cell lineage allocation.

Original languageEnglish
Title of host publicationEnvironmental Chemistry
Subtitle of host publicationNew Techniques and Data
Number of pages13
ISBN (Electronic)9781466558496
ISBN (Print)9781926692777
Publication statusPublished - 1 Jan 2011
Externally publishedYes


  • Blastocysts
  • Immunofluorescence
  • Periconceptional
  • Pre-implantation embryo

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