Morning or evening dosing with low-dose omeprazole: Effects on 24-hour gastric acidity profiles in duodenal ulcer patients

Neville D. Yeomans, Peter J. Prichard, D. Brian Jones, Peter J. Buckle, John J. Mcneil, William J. Louis, Richard A. Smallwood

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Previous studies with omeprazole have demonstrated that a daily dose of 30 or 40 mg reduces the acidity of gastric contents throughout the 24-hour period (1, 2). The influence of dosing time has been examined with 40 mg given either in the morning or in the evening (1). A dose at 0900 hours produced a slightly greater overall elevation in 24-hour pH than did dosing at 2100 hours. Inhibition of gastric acidity was nearly complete with either regimen, so that the difference between them was of doubtful therapeutic significance. At a lower dose, which may be considered for maintenance therapy, the time of administration may be more important. Therefore, 24-hour gastric pH profiles were examined in duodenal ulcer patients given omeprazole, 10 mg, in the morning or the evening.

Original languageEnglish
Pages (from-to)152-153
Number of pages2
JournalScandinavian Journal of Gastroenterology
Issue numberS118
Publication statusPublished - 1 Jan 1986
Externally publishedYes

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