More than one reason to rethink the use of peptides in vaccine design

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Abstract

The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines.
Original languageEnglish
Pages (from-to)404 - 414
Number of pages11
JournalNature Reviews Drug Discovery
Volume6
Issue number5
Publication statusPublished - 2007

Cite this

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title = "More than one reason to rethink the use of peptides in vaccine design",
abstract = "The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines.",
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More than one reason to rethink the use of peptides in vaccine design. / Purcell, Anthony W; McCluskey, James; Rossjohn, Jamie.

In: Nature Reviews Drug Discovery, Vol. 6, No. 5, 2007, p. 404 - 414.

Research output: Contribution to journalArticleResearchpeer-review

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