Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 404 - 414 |
| Number of pages | 11 |
| Journal | Nature Reviews Drug Discovery |
| Volume | 6 |
| Issue number | 5 |
| Publication status | Published - 2007 |
Cite this
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More than one reason to rethink the use of peptides in vaccine design. / Purcell, Anthony W; McCluskey, James; Rossjohn, Jamie.
In: Nature Reviews Drug Discovery, Vol. 6, No. 5, 2007, p. 404 - 414.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - More than one reason to rethink the use of peptides in vaccine design
AU - Purcell, Anthony W
AU - McCluskey, James
AU - Rossjohn, Jamie
PY - 2007
Y1 - 2007
N2 - The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines.
AB - The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17473845
M3 - Article
VL - 6
SP - 404
EP - 414
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
SN - 1474-1776
IS - 5
ER -