Mood disorders and immunity

Adam K. Walker, Robert Dantzer, Keith W. Kelley

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)


Depression is a common comorbid condition in substance abuse disorders. In particular, comorbidity between alcoholism and depression occurs with extremely high prevalence in the general population. Early studies investigating this dual diagnosis issue reported alcohol abuse to occur in almost a quarter of patients with affective disorders [1, 2]. Prevalence rises as high as 32 % if other substance abuse disorders are included [2]. These findings made it clear that enormous challenges lie ahead in tracing the individual etiology of substance abuse and depression, let alone their interaction. Clearly, this dilemma was to produce further difficulties in providing adequate and appropriate treatment for sufferers.

Original languageEnglish
Title of host publicationNeural-Immune Interactions in Brain Function and Alcohol Related Disorders
EditorsChanghai Cui, Lindsey Grandison, Antonio Noronha
Place of PublicationBoston MA USA
Number of pages43
ISBN (Electronic)9781461447290
ISBN (Print)9781461447283
Publication statusPublished - 1 Oct 2013
Externally publishedYes

Cite this

Walker, A. K., Dantzer, R., & Kelley, K. W. (2013). Mood disorders and immunity. In C. Cui, L. Grandison, & A. Noronha (Eds.), Neural-Immune Interactions in Brain Function and Alcohol Related Disorders (pp. 167-209). Springer.