TY - JOUR
T1 - Monoclonal antibody to murine neutrophils
T2 - Identification of the Gm-2.2 specificity
AU - Hibbs, Margaret L.
AU - Hogarth, P. Mark
AU - Scott, Bernadette M.
AU - Harris, Robert A.
AU - McKenzie, Ian F. C.
PY - 1984/12/1
Y1 - 1984/12/1
N2 - A neutrophil-specific alloantigen (Gm-2.2) was defined by a monoclonal antibody, 5119-4/7. The Gm-2.2 antigen is found only on bone marrow neutrophils or calcium caseinate-induced neutrophils and is absent from all lymphoid cells examined as well as adherent thioglycollate-induced peritoneal exudate cells and the nonhemopoietic tissues, kidney, liver, heart, brain, and red blood cells. Furthermore, unlike mature neutrophils, granulocyte/macrophage progenitor cells are Gm-2.2-, suggesting that Gm-2.2 is a differentiation antigen for the neutrophil series, the Gm-2 locus is linked to, but distinct from, the Ly-6 locus.
AB - A neutrophil-specific alloantigen (Gm-2.2) was defined by a monoclonal antibody, 5119-4/7. The Gm-2.2 antigen is found only on bone marrow neutrophils or calcium caseinate-induced neutrophils and is absent from all lymphoid cells examined as well as adherent thioglycollate-induced peritoneal exudate cells and the nonhemopoietic tissues, kidney, liver, heart, brain, and red blood cells. Furthermore, unlike mature neutrophils, granulocyte/macrophage progenitor cells are Gm-2.2-, suggesting that Gm-2.2 is a differentiation antigen for the neutrophil series, the Gm-2 locus is linked to, but distinct from, the Ly-6 locus.
UR - http://www.scopus.com/inward/record.url?scp=0021689922&partnerID=8YFLogxK
M3 - Article
C2 - 6207238
AN - SCOPUS:0021689922
SN - 0022-1767
VL - 133
SP - 2619
EP - 2623
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -