Monoclonal antibody to murine neutrophils: Identification of the Gm-2.2 specificity

Margaret L. Hibbs, P. Mark Hogarth, Bernadette M. Scott, Robert A. Harris, Ian F. C. McKenzie

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Abstract

A neutrophil-specific alloantigen (Gm-2.2) was defined by a monoclonal antibody, 5119-4/7. The Gm-2.2 antigen is found only on bone marrow neutrophils or calcium caseinate-induced neutrophils and is absent from all lymphoid cells examined as well as adherent thioglycollate-induced peritoneal exudate cells and the nonhemopoietic tissues, kidney, liver, heart, brain, and red blood cells. Furthermore, unlike mature neutrophils, granulocyte/macrophage progenitor cells are Gm-2.2-, suggesting that Gm-2.2 is a differentiation antigen for the neutrophil series, the Gm-2 locus is linked to, but distinct from, the Ly-6 locus.

Original languageEnglish
Pages (from-to)2619-2623
Number of pages5
JournalJournal of Immunology
Volume133
Issue number5
Publication statusPublished - 1 Dec 1984
Externally publishedYes

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