Research output per year
Research output per year
Ben Fancke, Meredith O'Keeffe
Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
Since the 1997 discovery that the fi rst identified human homologue of Drosophila Toll could activate the innate immune system, the innate arm of immunity has rapidly taken on a new light as an important player in the recognition of pathogens and damaged self. The recognition of danger by dendritic cells (DC) is a crucial step in activating the adaptive immune system. Different DC express varied subsets of pattern recognition receptors (PRR), enabling both overlap and exclusivity in the recognition of danger signals by DC. PRR-mediated DC maturation and activation can be measured by changes in the surface expression of costimulatory molecules and changes in size and shape of the DC and by their production of different cytokines.
Original language | English |
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Title of host publication | Antigen Processing: Methods and Protocols |
Editors | Peter van Endert |
Place of Publication | New York NY USA |
Publisher | Humana Press |
Chapter | 26 |
Pages | 359-370 |
Number of pages | 12 |
Edition | 1 |
ISBN (Electronic) | 9781627032186 |
ISBN (Print) | 9781627032179 |
DOIs | |
Publication status | Published - 2013 |
Name | Methods in Molecular Biology |
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Publisher | Human Press |
Volume | 960 |
ISSN (Print) | 1064-3745 |
ISSN (Electronic) | 1940-6029 |
Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review