Monash Vision Group's Gennaris cortical implant for vision restoration

Arthur James Lowery, Jeffrey V. Rosenfeld, Marcello G. P. Rosa, Emma Brunton, Ramesh Rajan, Collette Mann, Mark Armstrong, Anand Mohan, Horace Josh, Lindsay Kleeman, Wai Ho Li, Jeanette Pritchard

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

The Gennaris bionic vision system is a wireless device that has been designed to directly stimulate the primary visual cortex to restore useful vision to people with bilateral, irreversible blindness. Here, we describe the end-to-end system and the design of each component. The rationale for design decisions is provided,including the benefits of cortical stimulation, the need for wireless power and data transmission and the format of the autonomous implant tiles and penetrating micro-electrode arrays. We discuss the broad population of people for which this device may provide benefit, with reference to specific indications of blindness.
Details of laboratory and preclinical tests that we have used to verify the electrical functionality of the device are described. A description of the surgical method that has been developed for implanting tiles in the visual cortex is provided, which will be used to demonstrate proof-of-concept of the system in first-in-human studies. Highlighted is the importance of post-surgical device calibration, psychophysics testing and training of recipients in using the system in both controlled and unsupervised environments. Signal processing algorithms that have been developedto enhance the user experience are described and details provided of how these have been tested to optimise their integration into the full system. Finally, we describe how the Gennaris technology can be applied to a broad spectrum of other technological and health-related challenges.
Original languageEnglish
Title of host publicationArtificial Vision
Subtitle of host publicationA Clinical Guide
EditorsViet Peter Gabel
Place of PublicationCham, Switzerland
PublisherSpringer
Pages215-225
Number of pages11
ISBN (Electronic)9783319418766
ISBN (Print)9783319418742
DOIs
Publication statusPublished - 2017

Keywords

  • Cortical stimulation
  • Bionic vision
  • Wireless link
  • Implant tile
  • Hermetic
  • Penetrating electrodes
  • Annulus
  • Neurosurgery
  • Neural plasticity
  • Academic-industry partnership

Cite this

Lowery, A. J., Rosenfeld, J. V., Rosa, M. G. P., Brunton, E., Rajan, R., Mann, C., ... Pritchard, J. (2017). Monash Vision Group's Gennaris cortical implant for vision restoration. In V. P. Gabel (Ed.), Artificial Vision: A Clinical Guide (pp. 215-225). Cham, Switzerland: Springer. https://doi.org/10.1007/978-3-319-41876-6
Lowery, Arthur James ; Rosenfeld, Jeffrey V. ; Rosa, Marcello G. P. ; Brunton, Emma ; Rajan, Ramesh ; Mann, Collette ; Armstrong, Mark ; Mohan, Anand ; Josh, Horace ; Kleeman, Lindsay ; Li, Wai Ho ; Pritchard, Jeanette. / Monash Vision Group's Gennaris cortical implant for vision restoration. Artificial Vision: A Clinical Guide. editor / Viet Peter Gabel. Cham, Switzerland : Springer, 2017. pp. 215-225
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Lowery, AJ, Rosenfeld, JV, Rosa, MGP, Brunton, E, Rajan, R, Mann, C, Armstrong, M, Mohan, A, Josh, H, Kleeman, L, Li, WH & Pritchard, J 2017, Monash Vision Group's Gennaris cortical implant for vision restoration. in VP Gabel (ed.), Artificial Vision: A Clinical Guide. Springer, Cham, Switzerland, pp. 215-225. https://doi.org/10.1007/978-3-319-41876-6

Monash Vision Group's Gennaris cortical implant for vision restoration. / Lowery, Arthur James; Rosenfeld, Jeffrey V.; Rosa, Marcello G. P.; Brunton, Emma; Rajan, Ramesh; Mann, Collette; Armstrong, Mark; Mohan, Anand; Josh, Horace; Kleeman, Lindsay; Li, Wai Ho; Pritchard, Jeanette.

Artificial Vision: A Clinical Guide. ed. / Viet Peter Gabel. Cham, Switzerland : Springer, 2017. p. 215-225.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AU - Brunton, Emma

AU - Rajan, Ramesh

AU - Mann, Collette

AU - Armstrong, Mark

AU - Mohan, Anand

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AU - Li, Wai Ho

AU - Pritchard, Jeanette

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N2 - The Gennaris bionic vision system is a wireless device that has been designed to directly stimulate the primary visual cortex to restore useful vision to people with bilateral, irreversible blindness. Here, we describe the end-to-end system and the design of each component. The rationale for design decisions is provided,including the benefits of cortical stimulation, the need for wireless power and data transmission and the format of the autonomous implant tiles and penetrating micro-electrode arrays. We discuss the broad population of people for which this device may provide benefit, with reference to specific indications of blindness. Details of laboratory and preclinical tests that we have used to verify the electrical functionality of the device are described. A description of the surgical method that has been developed for implanting tiles in the visual cortex is provided, which will be used to demonstrate proof-of-concept of the system in first-in-human studies. Highlighted is the importance of post-surgical device calibration, psychophysics testing and training of recipients in using the system in both controlled and unsupervised environments. Signal processing algorithms that have been developedto enhance the user experience are described and details provided of how these have been tested to optimise their integration into the full system. Finally, we describe how the Gennaris technology can be applied to a broad spectrum of other technological and health-related challenges.

AB - The Gennaris bionic vision system is a wireless device that has been designed to directly stimulate the primary visual cortex to restore useful vision to people with bilateral, irreversible blindness. Here, we describe the end-to-end system and the design of each component. The rationale for design decisions is provided,including the benefits of cortical stimulation, the need for wireless power and data transmission and the format of the autonomous implant tiles and penetrating micro-electrode arrays. We discuss the broad population of people for which this device may provide benefit, with reference to specific indications of blindness. Details of laboratory and preclinical tests that we have used to verify the electrical functionality of the device are described. A description of the surgical method that has been developed for implanting tiles in the visual cortex is provided, which will be used to demonstrate proof-of-concept of the system in first-in-human studies. Highlighted is the importance of post-surgical device calibration, psychophysics testing and training of recipients in using the system in both controlled and unsupervised environments. Signal processing algorithms that have been developedto enhance the user experience are described and details provided of how these have been tested to optimise their integration into the full system. Finally, we describe how the Gennaris technology can be applied to a broad spectrum of other technological and health-related challenges.

KW - Cortical stimulation

KW - Bionic vision

KW - Wireless link

KW - Implant tile

KW - Hermetic

KW - Penetrating electrodes

KW - Annulus

KW - Neurosurgery

KW - Neural plasticity

KW - Academic-industry partnership

UR - http://www.springer.com/la/book/9783319418742

U2 - 10.1007/978-3-319-41876-6

DO - 10.1007/978-3-319-41876-6

M3 - Chapter (Book)

SN - 9783319418742

SP - 215

EP - 225

BT - Artificial Vision

A2 - Gabel, Viet Peter

PB - Springer

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ER -

Lowery AJ, Rosenfeld JV, Rosa MGP, Brunton E, Rajan R, Mann C et al. Monash Vision Group's Gennaris cortical implant for vision restoration. In Gabel VP, editor, Artificial Vision: A Clinical Guide. Cham, Switzerland: Springer. 2017. p. 215-225 https://doi.org/10.1007/978-3-319-41876-6