Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function

Daria Bongiorno, Steven Petratos

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Nogo-A is part of the reticulon family of proteins localized to the myelin and oligodendroglial plasma membranes. Nogo-A specifically initiates signal transduction cascades limiting axonal regrowth following injury and disease in the adult mammalian central nervous system (CNS). Recent novel data support the contention that neuronal Nogo-A plays an important role in regulating cytoskeletal re-organization without the requirement of signaling through its cognate receptor (Nogo receptor). These data, along with the recent findings that the N-terminus of Nogo-A can interact with integrins and that NgR1 interacts with the amyloid precursor protein extracellularly, as well as novel findings showing ubiquitin ligases binding with Nogo-A intracellularly add a layer of complexity to its functional role in the CNS.
Original languageEnglish
Pages (from-to)1072 - 1075
Number of pages4
JournalInternational Journal of Biochemistry & Cell Biology
Volume42
Issue number7
DOIs
Publication statusPublished - 2010
Externally publishedYes

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