Molecular pathways for lymphangiogenesis and their role in human disease

Steven A Stacker; Rae Helen Farnsworth; Tara Karnezis; Ramin Shayan; Darrin P Smith; Karri Paavonen; Natalia Davydova; Carol Caesar; Rachael Inder; Megan E Baldwin; Bradley K McColl; Sally Roufail; Richard A Williams; Richard A Hughes; Kari Alitalo; Marc G Achen

doi:10.1002/9780470062128.ch4

Molecular pathways for lymphangiogenesis and their role in human disease

Steven A Stacker, Rae Helen Farnsworth, Tara Karnezis, Ramin Shayan, Darrin P Smith, Karri Paavonen, Natalia Davydova, Carol Caesar, Rachael Inder, Megan E Baldwin, Bradley K McColl, Sally Roufail, Richard A Williams, Richard A Hughes, Kari Alitalo, Marc G Achen

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.

Original language	English
Pages (from-to)	38 - 43
Number of pages	6
Journal	Novartis Foundation Symposium
Volume	281
DOIs	https://doi.org/10.1002/9780470062128.ch4
Publication status	Published - 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/9780470062128.ch4

Cite this

Stacker, S. A., Farnsworth, R. H., Karnezis, T., Shayan, R., Smith, D. P., Paavonen, K., Davydova, N., Caesar, C., Inder, R., Baldwin, M. E., McColl, B. K., Roufail, S., Williams, R. A., Hughes, R. A., Alitalo, K., & Achen, M. G. (2007). Molecular pathways for lymphangiogenesis and their role in human disease. Novartis Foundation Symposium, 281, 38 - 43. https://doi.org/10.1002/9780470062128.ch4

@article{a90cad52d09443979cdf62f164cd3811,

title = "Molecular pathways for lymphangiogenesis and their role in human disease",

abstract = "The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.",

author = "Stacker, {Steven A} and Farnsworth, {Rae Helen} and Tara Karnezis and Ramin Shayan and Smith, {Darrin P} and Karri Paavonen and Natalia Davydova and Carol Caesar and Rachael Inder and Baldwin, {Megan E} and McColl, {Bradley K} and Sally Roufail and Williams, {Richard A} and Hughes, {Richard A} and Kari Alitalo and Achen, {Marc G}",

year = "2007",

doi = "10.1002/9780470062128.ch4",

language = "English",

volume = "281",

pages = "38 -- 43",

journal = "Novartis Foundation Symposium",

issn = "1528-2511",

publisher = "John Wiley & Sons",

}

Stacker, SA, Farnsworth, RH, Karnezis, T, Shayan, R, Smith, DP, Paavonen, K, Davydova, N, Caesar, C, Inder, R, Baldwin, ME, McColl, BK, Roufail, S, Williams, RA, Hughes, RA, Alitalo, K & Achen, MG 2007, 'Molecular pathways for lymphangiogenesis and their role in human disease', Novartis Foundation Symposium, vol. 281, pp. 38 - 43. https://doi.org/10.1002/9780470062128.ch4

TY - JOUR

T1 - Molecular pathways for lymphangiogenesis and their role in human disease

AU - Stacker, Steven A

AU - Farnsworth, Rae Helen

AU - Karnezis, Tara

AU - Shayan, Ramin

AU - Smith, Darrin P

AU - Paavonen, Karri

AU - Davydova, Natalia

AU - Caesar, Carol

AU - Inder, Rachael

AU - Baldwin, Megan E

AU - McColl, Bradley K

AU - Roufail, Sally

AU - Williams, Richard A

AU - Hughes, Richard A

AU - Alitalo, Kari

AU - Achen, Marc G

PY - 2007

Y1 - 2007

N2 - The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.

AB - The lymphatic network functions to return fluid, cells and macromolecules to the circulation. Recent characterization of growth factors that control the growth and development of the lymphatics, and markers which specify lymphatic endothelial cells have enhanced our understanding of this system. Members of the VEGF family of factors are key regulators of these vessels with VEGF-C/VEGF-D and VEGFR-3 being the best validated signalling pathways in lymphangiogenesis. The study of these molecules in various pathologies has shown that they are important in the processes of cancer metastasis and in the formation of lymphoedema. Knowledge of these molecular pathways allows for the generation of modulators of these pathways which could form the basis of novel therapeutic approaches.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17534064

U2 - 10.1002/9780470062128.ch4

DO - 10.1002/9780470062128.ch4

M3 - Article

SN - 1528-2511

VL - 281

SP - 38

EP - 43

JO - Novartis Foundation Symposium

JF - Novartis Foundation Symposium

ER -

Molecular pathways for lymphangiogenesis and their role in human disease

Abstract

UN SDGs

Access to Document

Other files and links

Cite this