Molecular oncogenesis of prostate adenocarcinoma: Role of the human epidermal growth factor receptor 2 (HER-2/neu)

Ary Serpa Neto, Marcos Tobias-Machado, Marcelo Langer Wroclawski, Fernando Luiz Affonso Fonseca, Antonio Carlos Lima Pompeo, Auro Del Giglio

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Abstract

The potential mechanisms involving the genesis and growth of androgen-independent prostate cancer include super-expression of the androgen receptor (AR), in an attempt to compensate for the low androgenic plasma levels and mutations of this specific receptor, which could determine resistance to anti-androgenic therapy. However, most advanced prostate tumors have no mutations or amplifications of the AR, suggesting a potential role of non-androgenic growth factors, including epidermal growth factor (EGF), transforming growth factor α, insulin-like growth factor (IGF-1) and fibroblast growth factor. More specifically, these factors, and their receptors like EGFR (HER-1) and HER-2/neu, through paracrine and autocrine mechanisms, may contribute to the proliferation and growth of prostate cancer.

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalTumori
Volume96
Issue number5
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • HER-2
  • Oncogenesis
  • Prostate cancer

Cite this