Molecular modelling of β turns in a cyclic melanotropin

Ngai Chung Chan, Sarah K. Branch, Stephen H. Moss, Colin W. Pouton

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8 Citations (Scopus)

Abstract

α-Melanocyte stimulating hormone (α-MSH) is a tridecapeptide which interacts with a family of G protein-coupled receptors, the melanocortin receptors, to cause its biological effects. We have modelled the low energy conformations of the α-MSH derivatives as part of a project to probe the receptor binding conformation of melanocortins, and also to design ligands for targeting cytotoxic turns in a cyclic lactam analogue [Nle4,Asp5,D-Phe7,Lys10]α-MSH. The data show that it is possible for a β turn to exist in the ring portion of this molecule which contains the melanocortin conserved sequence -His-Phe-Arg-Trp-, even though the lowest energy conformers lack a β turn.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume48
Issue number2
DOIs
Publication statusPublished - 1 Jan 1996

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