α-Melanocyte stimulating hormone (α-MSH) is a tridecapeptide which interacts with a family of G protein-coupled receptors, the melanocortin receptors, to cause its biological effects. We have modelled the low energy conformations of the α-MSH derivatives as part of a project to probe the receptor binding conformation of melanocortins, and also to design ligands for targeting cytotoxic turns in a cyclic lactam analogue [Nle4,Asp5,D-Phe7,Lys10]α-MSH. The data show that it is possible for a β turn to exist in the ring portion of this molecule which contains the melanocortin conserved sequence -His-Phe-Arg-Trp-, even though the lowest energy conformers lack a β turn.
|Number of pages||5|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - 1 Jan 1996|