Abstract
Infiltration of T cells is a key step in the pathogenesis of the inflammatory skin
diseases atopic dermatitis, allergic contact dermatitis and psoriasis.
Understanding the mechanisms of T cell recruitment to the skin is therefore of
fundamental importance for the discovery and application of novel therapies
for these conditions. Studies of both clinical samples and experimental models
of skin inflammation have implicated specific adhesion molecules and
chemokines in lymphocyte recruitment. In particular, recent studies using
advanced in vivo imaging techniques have greatly increased our
understanding of the kinetics and molecular basis of this process. In this
review, we summarise the current understanding of the cellular immunology of
antigen-driven dermal inflammation and the roles of adhesion molecules and
chemokines. We focus on results obtained using intravital microscopy to
examine the dermal microvasculature and interstitium to determine the
mechanisms of T cell recruitment and migration in experimental models of
T-cell-mediated skin inflammation.
Original language | English |
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Pages (from-to) | 1 - 21 |
Number of pages | 21 |
Journal | Expert Reviews in Molecular Medicine |
Volume | 11 |
Issue number | e25 |
DOIs | |
Publication status | Published - 2009 |