Molecular machinations of the MHC-I peptide loading complex

Anthony W. Purcell, Tim Elliott

Research output: Contribution to journalReview ArticleResearchpeer-review

44 Citations (Scopus)

Abstract

The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalCurrent Opinion in Immunology
Volume20
Issue number1
DOIs
Publication statusPublished - 1 Feb 2008
Externally publishedYes

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