Molecular imaging and orientational changes of antimicrobial peptides in membranes

Tzong-Hsien Lee, Kristopher Norman Hall, Adam Istvan Mechler, Lisandra Lorraine Martin, Jonathan Popplewell, Gerry Ronan, Marie Isabel Aguilar

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

4 Citations (Scopus)

Abstract

The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides. The approximately one thousand members of the Society come from North America and from more than thirty other countries throughout the world. Establishment of the APS was a result of the rapid worldwide growth that has occurred in peptide-related research, and of the increasing interaction of peptide scientists with virtually all fields of science. Peptides for Youth: The Proceedings of the the 20th American Peptide Symposium will highlight many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. The 20th American Peptide Symposium will take place June 26 - 30, 2007 in Montreal, Canada. Resistance to conventional antibiotics has placed antimicrobial peptides under the spotlight as alternative therapeutics for microbial infections. However, the design of specific non-toxic peptides has been elusive due largely to our poor understanding of the precise mechanism of cell lysis. Specifically, the difficulty in defining peptide conformation and location in membranes needs to be addressed. We have used a combination of dual polarisation interferometry (DPI), surface plasmon resonance spectroscopy (SPR) and atomic force microscopy (AFM) to gain an unprecedented detailed molecular picture of membrane lysis by antimicrobial peptides
Original languageEnglish
Title of host publicationPeptides for Youth: The Proceedings of the 20th American Peptide Symposium
EditorsSusan Del Valle, Emanuel Escher, William D Lube
Place of PublicationUSA
PublisherSpringer
Pages313 - 315
Number of pages3
Edition611
ISBN (Print)9780387736563
Publication statusPublished - 2009

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