Abstract
The mineralocorticoid receptor (MR) responds not only to the physiological mineralocorticoids, aldosterone and deoxycorticosterone, but also to the physiological glucocorticoid, cortisol. The MR is a member of the nuclear receptor superfamily that acts as a ligand-dependent transcription factor. The structural determinants of MR function are described and discussed. The MR mediates its effects not only through a transcriptional mechanism but also through nongenomic mechanisms and perhaps through transrepression. The nature of these responses is both ligand and tissue dependent. The MR is expressed in a number of tissues beyond the traditional epithelial targets for aldosterone, including the central nervous and the cardiovascular systems. Recent clinical studies have demonstrated the importance of the MR as a therapeutic target.
Original language | English |
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Title of host publication | Hormones, Brain and Behavior Online |
Publisher | Academic Press |
Pages | 1421-1439 |
Number of pages | 19 |
ISBN (Print) | 9780080887838 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |
Keywords
- Aldosterone
- Coactivator
- Cortisol
- ENaC
- Glucocorticoids
- Hypertension
- Nuclear receptor
- Serum
- SGK
- Sodium
- Transcription
- Transrepression