Molecular features of lipid-based antigen presentation by group 1 CD1 molecules

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Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group 3 (CD1e). While CD1d-mediated T-cell immunity has been extensively investigated, we have only recently gained insights into the structure and function of group 1 CD1 molecules. Structural studies have revealed how lipid-based antigens are presented by group 1 CD1 molecules, as well as shedding light on the molecular requirements for T-cell recognition. Here, we provide an overview of our current understanding of lipid presentation by group 1 CD1 molecules in humans and their recognition by T-cells, as well as examining the potential differences in lipid presentation that may occur across different species.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalSeminars in Cell and Developmental Biology
Publication statusPublished - 1 Dec 2018


  • CD1 glycoproteins
  • CD1-mediated T-cell immunity
  • Lipid-based antigen presentation
  • MHC-like molecules
  • T-cell receptor recognition

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