Molecular events leading to the creation of a pandemic influenza virus

Shipra Sharma, Adarsh Mayank, Sunil K. Lal

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)


Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.

Original languageEnglish
Pages (from-to)332-338
Number of pages7
JournalIndian Journal of Microbiology
Issue number4
Publication statusPublished - Dec 2009
Externally publishedYes


  • Antigenic determinants
  • H1N1
  • Pandemic
  • Pathogenicity

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