TY - JOUR
T1 - Molecular events leading to the creation of a pandemic influenza virus
AU - Sharma, Shipra
AU - Mayank, Adarsh
AU - Lal, Sunil K.
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2009/12
Y1 - 2009/12
N2 - Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.
AB - Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.
KW - Antigenic determinants
KW - H1N1
KW - Pandemic
KW - Pathogenicity
UR - http://www.scopus.com/inward/record.url?scp=73549113337&partnerID=8YFLogxK
U2 - 10.1007/s12088-009-0059-0
DO - 10.1007/s12088-009-0059-0
M3 - Review Article
AN - SCOPUS:73549113337
VL - 49
SP - 332
EP - 338
JO - Indian Journal of Microbiology
JF - Indian Journal of Microbiology
SN - 0046-8991
IS - 4
ER -