Molecular diversity through sugar scaffolds

Giang Thanh Le, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Judy Halliday, Gerry Tometzki, Johannes Zuegg, Wim Meutermans

Research output: Contribution to journalReview ArticleResearchpeer-review

88 Citations (Scopus)

Abstract

Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.

Original languageEnglish
Pages (from-to)701-709
Number of pages9
JournalDrug Discovery Today
Volume8
Issue number15
DOIs
Publication statusPublished - 1 Aug 2003
Externally publishedYes

Keywords

  • Carbohydrate
  • Drug discovery
  • Libraries
  • Scaffold
  • Structural diversity

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