Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity

Research output: Contribution to journalReview ArticleOtherpeer-review

5 Citations (Scopus)

Abstract

It has widely been accepted that major histocompatibility complex class I molecules (MHC-I) are limited to binding small peptides of 8-10 residues in length. However, this consensus has recently been challenged with the identification of longer peptides (≥11 residues) that can also elicit cytotoxic CD8+ T cell responses. Indeed, a growing number of studies demonstrate that these non-canonical epitopes are important targets for the immune system. As long epitopes represent up to 10% of the peptide repertoire bound to MHC-I molecules, here we review their impact on antigen presentation by MHC-I, TCR recognition, and T cell immunity.

Original languageEnglish
Pages (from-to)1027-1036
Number of pages10
JournalBiological Chemistry
Volume398
Issue number9
DOIs
Publication statusPublished - 28 Aug 2017

Keywords

  • antigen presentation
  • human leukocyte antigen
  • major histocompatibility complex
  • T cell receptor recognition
  • tumor peptide
  • viral peptide

Cite this

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title = "Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity",
abstract = "It has widely been accepted that major histocompatibility complex class I molecules (MHC-I) are limited to binding small peptides of 8-10 residues in length. However, this consensus has recently been challenged with the identification of longer peptides (≥11 residues) that can also elicit cytotoxic CD8+ T cell responses. Indeed, a growing number of studies demonstrate that these non-canonical epitopes are important targets for the immune system. As long epitopes represent up to 10{\%} of the peptide repertoire bound to MHC-I molecules, here we review their impact on antigen presentation by MHC-I, TCR recognition, and T cell immunity.",
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Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity. / Josephs, Tracy M.; Grant, Emma J.; Gras, Stephanie.

In: Biological Chemistry, Vol. 398, No. 9, 28.08.2017, p. 1027-1036.

Research output: Contribution to journalReview ArticleOtherpeer-review

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AB - It has widely been accepted that major histocompatibility complex class I molecules (MHC-I) are limited to binding small peptides of 8-10 residues in length. However, this consensus has recently been challenged with the identification of longer peptides (≥11 residues) that can also elicit cytotoxic CD8+ T cell responses. Indeed, a growing number of studies demonstrate that these non-canonical epitopes are important targets for the immune system. As long epitopes represent up to 10% of the peptide repertoire bound to MHC-I molecules, here we review their impact on antigen presentation by MHC-I, TCR recognition, and T cell immunity.

KW - antigen presentation

KW - human leukocyte antigen

KW - major histocompatibility complex

KW - T cell receptor recognition

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