Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

Shanshan Ma; Qingya Shen; Li Hua Zhao; Chunyou Mao; X. Edward Zhou; Dan Dan Shen; Parker W. de Waal; Peng Bi; Chuntao Li; Yi Jiang; Ming Wei Wang; Patrick M. Sexton; Denise Wootten; Karsten Melcher; Yan Zhang; H. Eric Xu

doi:10.1016/j.molcel.2020.01.013

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

Shanshan Ma
, Qingya Shen
, Li Hua Zhao
, Chunyou Mao
, X. Edward Zhou
, Dan Dan Shen
, Parker W. de Waal
, Peng Bi
, Chuntao Li
, Yi Jiang
, Ming Wei Wang
, Patrick M. Sexton
, Denise Wootten
, Karsten Melcher
, Yan Zhang
, H. Eric Xu

Drug Discovery Biology

Research output: Contribution to journal › Article › Research › peer-review

76 Citations (Scopus)

Abstract

The fully active structures of CRF receptors reveal the basis for peptide-binding specificity, support a universal mechanism of class B GPCR activation, and provide detailed structural information for studying membrane protein-lipid interactions.

Original language	English
Pages (from-to)	669-680.e4
Number of pages	16
Journal	Molecular Cell
Volume	77
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.01.013
Publication status	Published - 6 Feb 2020

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Ma, S., Shen, Q., Zhao, L. H., Mao, C., Zhou, X. E., Shen, D. D., de Waal, P. W., Bi, P., Li, C., Jiang, Y., Wang, M. W., Sexton, P. M., Wootten, D., Melcher, K., Zhang, Y., & Xu, H. E. (2020). Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Molecular Cell, 77(3), 669-680.e4. https://doi.org/10.1016/j.molcel.2020.01.013

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title = "Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors",

abstract = "The fully active structures of CRF receptors reveal the basis for peptide-binding specificity, support a universal mechanism of class B GPCR activation, and provide detailed structural information for studying membrane protein-lipid interactions.",

author = "Shanshan Ma and Qingya Shen and Zhao, \{Li Hua\} and Chunyou Mao and Zhou, \{X. Edward\} and Shen, \{Dan Dan\} and \{de Waal\}, \{Parker W.\} and Peng Bi and Chuntao Li and Yi Jiang and Wang, \{Ming Wei\} and Sexton, \{Patrick M.\} and Denise Wootten and Karsten Melcher and Yan Zhang and Xu, \{H. Eric\}",

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doi = "10.1016/j.molcel.2020.01.013",

language = "English",

volume = "77",

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journal = "Molecular Cell",

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T1 - Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

AU - Ma, Shanshan

AU - Shen, Qingya

AU - Zhao, Li Hua

AU - Mao, Chunyou

AU - Zhou, X. Edward

AU - Shen, Dan Dan

AU - de Waal, Parker W.

AU - Bi, Peng

AU - Li, Chuntao

AU - Jiang, Yi

AU - Wang, Ming Wei

AU - Sexton, Patrick M.

AU - Wootten, Denise

AU - Melcher, Karsten

AU - Zhang, Yan

AU - Xu, H. Eric

PY - 2020/2/6

Y1 - 2020/2/6

N2 - The fully active structures of CRF receptors reveal the basis for peptide-binding specificity, support a universal mechanism of class B GPCR activation, and provide detailed structural information for studying membrane protein-lipid interactions.

AB - The fully active structures of CRF receptors reveal the basis for peptide-binding specificity, support a universal mechanism of class B GPCR activation, and provide detailed structural information for studying membrane protein-lipid interactions.

UR - https://www.scopus.com/pages/publications/85078737093

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DO - 10.1016/j.molcel.2020.01.013

M3 - Article

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AN - SCOPUS:85078737093

SN - 1097-2765

VL - 77

SP - 669-680.e4

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

Abstract

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