Molecular analysis of the virulence determinants of enterotoxigenic Escherichia coli isolated from domestic animals: Applications for vaccine development

Gordon Dougan, Pierre Morrissey

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Enterotoxigenic strains of Escherichia coli are an important cause of diarrhoeal disease in young farm animals. Several virulence determinants have been shown to play a major role in the pathogenicity of these strains. The molecular structure of some of these determinants including adhesion fimbriae, heat-labile toxins and heat-stable toxins have been elucidated. This knowledge has made possible the development of novel vaccines effective against enterotoxigenic strains. In this short review, the structure of these virulence factors will be described and the implications for the development of future vaccines will be discussed.

Original languageEnglish
Pages (from-to)241-257
Number of pages17
JournalVeterinary Microbiology
Issue number3
Publication statusPublished - 1 Jan 1985
Externally publishedYes

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