TY - JOUR
T1 - Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats
AU - Kondamudi, Phani Krishna
AU - Kovelamudi, Hemalatha
AU - Mathew, Geetha
AU - Nayak, Pawan G.
AU - Mallikarjuna Rao, C.
AU - Shenoy, Rekha R.
PY - 2013
Y1 - 2013
N2 - Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. Methods: The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. Results: The levels of MPO, TBARS and nitrite increased significantly (p < 0.05) in the DNCB group, whereas reduced significantly in the SES, SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. IL-6 and TNF-α levels were significantly high in the DNCB group. Conclusions:We conclude the mucosal protective effect of SESon colon due to its potent antioxidant actions. Further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway.
AB - Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. Methods: The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. Results: The levels of MPO, TBARS and nitrite increased significantly (p < 0.05) in the DNCB group, whereas reduced significantly in the SES, SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. IL-6 and TNF-α levels were significantly high in the DNCB group. Conclusions:We conclude the mucosal protective effect of SESon colon due to its potent antioxidant actions. Further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway.
KW - Dinitrochlorobenzene
KW - Interleukin-6
KW - Myeloperoxidase
KW - Sesamol
KW - TBARS
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=84884489093&partnerID=8YFLogxK
M3 - Article
C2 - 23950588
AN - SCOPUS:84884489093
SN - 1734-1140
VL - 65
SP - 658
EP - 665
JO - Pharmacological Reports
JF - Pharmacological Reports
IS - 3
ER -