Modulatory effects of estrogens on grooming and related behaviors

Rachel A. Hill, Wah Chin Boon

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

Summary Both the estrogen-synthesizing enzyme and estrogen receptors are present in the brain. The distribution of estrogen-sensitive cells in the brain corresponds to regions that control sexual differentiation, masculine and feminine sexual behaviors, and aggressive behaviors as well as grooming. All these are indicative that estrogens play diverse roles in several neural circuits. From observing animal models and psychiatric patients, it is evident that estrogens have modulatory effects on grooming and related behaviors. Introduction Traditionally viewed as female reproductive hormones, estrogens have in the past decade been shown to have widespread biological actions in both males and females. Estrogens are C-18 steroids derived from cholesterol and occur naturally in the human body in three different forms: 17β-estradiol (E2), estrone (E1), and estriol (E3) (Young et al. 1964). The last step in estrogen biosynthesis is the aromatization of androgens, including testosterone and androstenedione, to estradiol and estrone respectively. In addition to the reproductive organs, estrogens are expressed in many tissues including: breast, fat, muscle, bone, and brain (Carreau et al. 1999; Jenkins et al. 1993; Sasano and Ozaki 1997; Sasano et al. 1997, 1998; Simpson et al. 1997a). Investigations on the mechanism of action of estrogens have escalated greatly over the past decade due to the discovery of three types of estrogen receptors: estrogen receptor α (ERα; Green et al. 1986) estrogen receptor β (ERβ; Kuiper et al. 1996), and membrane ER (ERX; Watson et al. 1999). However, the last is probably ERα in most cases.

Original languageEnglish
Title of host publicationNeurobiology of Grooming Behavior
PublisherCambridge University Press (Anthem Press)
Pages108-130
Number of pages23
ISBN (Electronic)9780511676109
ISBN (Print)9780521116381
DOIs
Publication statusPublished - 1 Jan 2010
Externally publishedYes

Cite this

Hill, R. A., & Boon, W. C. (2010). Modulatory effects of estrogens on grooming and related behaviors. In Neurobiology of Grooming Behavior (pp. 108-130). Cambridge University Press (Anthem Press). https://doi.org/10.1017/CBO9780511676109.007